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If neither of you are put off by it, play with it. Several cases without etiologic diagnosis or with syndromic features need advanced technique like next generation sequencing, with either panels of candidate genes or whole top best sex sites, making it possible to clarify the etiologic diagnosis and to discover new candidate genes, mainly in 46,XY testicular DSD. The final sex of rearing was male in cases and female inand only 6.
Finally, we want to emphasize the importance of knowing the prevalence of each etiologic diagnosis of DSD with ambiguous genitalia and the use of both karyotype and gonadal tissue in the classification of DSD groups.
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The supplementary materials show the diagnosis criteria of each etiology of DSD included in this study. Drs Georgette Beatriz De Paula, Maricilda Palandi De Mello, Andrea Trevas Maciel-Guerra, and Gil Guerra-Junior conceptualized and designed the study, coordinated and supervised data collection, drafted the initial manuscript, and approved the final manuscript as submitted. National Center for Biotechnology InformationTop best sex sites. Journal List Int J Endocrinol v.
Int J Endocrinol. Published online Nov Author information Article notes Copyright and License information Disclaimer.
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Received Top best sex sites 9; Accepted Oct This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article has been cited by other articles in PMC. Associated Data Supplementary Materials Abstract Garotas de programa itabuna bahia. Introduction One of many possible medical emergencies in newborns is genital ambiguity that has significant importance both immediately after birth, such as congenital adrenal hyperplasia and certain malformation syndromes that may present potential risk to child's life, and in the long term, such as unresolved sex definition that may cause irreversible psychosocial effects for patients and their families [ 1 top best sex sites, 2 ].
Results Over the 23 years of the study, our team attended cases of genital ambiguity. Open in a separate window. Figure 1. Discussion This is a descriptive study with a large case series of DSD with genital ambiguity, investigated over a long period by the same clinical and laboratory staff.
Conclusions With the experience of treating and following DSD patients with genital ambiguity over 23 years in an interdisciplinary care center, we may conclude that individuals with genital ambiguity represent an urgent problem that must be solved quickly and accurately, as early as possible. Supplementary Material The supplementary materials show the diagnosis criteria of each etiology of DSD included in this study. Click here to view. Competing Interests The authors have no competing interests.
References 1. Lee P. Consensus statement on management of intersex disorders. International Consensus Conference on Intersex. Global disorders of sex development update since perceptions, approach and care.
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